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Ss-31 Elamipretide
Elamipretide (SS-31) MTP-131 Bendavia
Product Name:Elamipretide
Synonyms:Elamipretide (SS-31),MTP-131,Bendavia
CAS No.:736992-21-5
Catalog No.:GT-L004
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Key Specification:
Appearance: White powder
Purity (HPLC) ≥98.0%
Single impurity≤1.5%
Peptide content≥70.0%
Bacterial Endotoxins≤30EU/mg
Application:
SS-31 peptide, also known as Elamipretide, is a synthetic tetrapeptide (amino acid sequence: D-Arg-Dmt-L-Lys-D-Ala) designed to target and protect mitochondrial membranes. First identified for its ability to interact with cardiolipin (CL), a phospholipid exclusively located in the inner mitochondrial membrane, SS-31 has been studied for its role in mitigating mitochondrial dysfunction associated with various diseases.
The peptide's structure features a cyclic conformation that allows high-affinity binding to cardiolipin, a key lipid critical for maintaining mitochondrial membrane integrity and function.
By binding to cardiolipin, SS-31 stabilizes the mitochondrial inner membrane, reduces oxidative stress, and inhibits mitochondrial permeability transition pore (mPTP) opening-an event linked to mitochondrial dysfunction and cell apoptosis. Additionally, it protects mitochondrial electron transport chain complexes, enhancing ATP production and reducing reactive oxygen species (ROS) generation.
Product Benefits:
SS-31 has been investigated in preclinical and clinical studies for conditions associated with mitochondrial dysfunction, including:
Cardiovascular Diseases: Such as heart failure, myocardial infarction, and diabetic cardiomyopathy, where it improves
cardiac function and reduces ischemia-reperfusion injury.
Neurological Disorders: Including Alzheimer's disease, Parkinson's disease, and stroke, by protecting neurons from mitochondrial stress.
Age-Related Diseases: Targeting cellular aging through mitochondrial maintenance.
Ophthalmic Conditions: Such as dry eye disease and retinitis pigmentosa, by restoring ocular surface epithelial cell function.
Mitochondrial Protection: Guards against oxidative damage and promotes mitochondrial stability.
Anti-Apoptotic Effects: Prevents cell death by inhibiting mPTP-dependent and mPTP-independent apoptotic pathways.
Inflammatory Regulation: Modulates inflammatory responses by reducing ROS-mediated signaling.
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